Preheat oven to 350 degrees F.
In a large skillet, brown the ground chuck over medium-high heat, about 7-9 minutes, breaking it up as it cooks. Reserve 3 Tbsp of fat, then drain all but 1-2 Tbsp.
Add onion powder, garlic powder, smoked paprika, Worcestershire sauce, salt and pepper, cooking for 2-3 more minutes and mixing to incorporate the seasoning thoroughly. Add additional salt to taste, then transfer to a bowl and set aside.
Cook the bacon in the same skillet until browned and crispy, about 7 minutes, then transfer to a paper towel-lined plate. Do not drain bacon fat.
Add the mushrooms and onions to the same skillet with the bacon fat, and cook until browned and the onions start to caramelize, about 7-8 minutes.